Bioactive Small Molecules
A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.
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Tocris Bioscience™ BGC 20-1531 hydrochloride
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High affinity and selective EP4 antagonist
Tocris Bioscience™ JNJ 1013
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Interleukin 1 Receptor Associated Kinase 1 (IRAK1) PROTAC™
Tocris Bioscience™ BI-6901
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Potent and selective CCR10 antagonist
Tocris Bioscience™ MS 023 dihydrochloride
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Potent and selective type I PRMT inhibitor
| Target | Histone Methyltransferase Inhibitors |
|---|---|
| CAS | 1992047-64-9 |
| Purity | >98% |
| Chemical Name or Material | N1-Methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-1,2-ethanediamine dihydrochloride |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C17H25N3O.2HCl |
| Formula Weight | 360.32 |
Tocris Bioscience™ MDL 72222
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CAS: 40796-97-2 Molecular Formula: C15H17Cl2NO2
| CAS | 40796-97-2 |
|---|---|
| Molecular Formula | C15H17Cl2NO2 |
Tocris Bioscience™ StemRegenin 1
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Aryl hydrocarbon receptor (AhR) antagonist; promotes HSC expansion and engraftment
Tocris Bioscience™ LY 404187
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Selective AMPA receptor positive allosteric modulator
| Target | AMPA Receptor Modulators |
|---|---|
| CAS | 211311-95-4 |
| Purity | >98% |
| Chemical Name or Material | N-[2-(4′-Cyano[1,1′-biphenyl]-4-yl)propyl]-2-propanesulfonamide |
| Recommended Storage | Store at 4°C |
| Molecular Formula | C19H22N2O2S |
| Formula Weight | 342.46 |
Tocris Bioscience™ N-Acetylcysteine amide
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Glutathione (GSH) precursor; neuroprotective
| Target | Additional Antioxidant Compounds |
|---|---|
| CAS | 38520-57-9 |
| Chemical Name or Material | (2R)-2-(Acetylamino)-3-mercaptopropanamide |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C5H10N2O2S |
| Formula Weight | 162.21 |
Tocris Bioscience™ A 425619
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Potent TRPV1 antagonist
| Target | TRPV Antagonists |
|---|---|
| CAS | 581809-67-8 |
| Purity | >98% |
| Chemical Name or Material | N-5-Isoquinolinyl-N′-[[(4-(trifluoromethyl)phenyl]methyl]urea |
| Recommended Storage | Store at Room Temperature |
| Molecular Formula | C18H14F3N3O |
| Formula Weight | 345.32 |
Tocris Bioscience™ Thalidomide 5'-amine-alkylC10-amine
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Cereblon ligand with alkyl linker and terminal amine for onward chemistry
Tocris Bioscience™ PF 06273340
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Potent and selective pan-Trk inhibitor; peripherally restricted
Tocris Bioscience™ BS 181 dihydrochloride
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Selective cdk7 inhibitor
| Target | Cyclin-dependent Kinase Inhibitors |
|---|---|
| CAS | 1883548-83-1 |
| Purity | >99% |
| Chemical Name or Material | N5-(6-Aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine dihydrochloride |
| Recommended Storage | Store at 4°C |
| Molecular Formula | C22H32N6.2HCl |
| Formula Weight | 453.45 |
Tocris Bioscience™ VTP 27999 trifluoroacetate
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Highly potent and selective renin inhibitor
Tocris Bioscience™ Eeyarestatin I
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CAS: 412960-54-4 Molecular Formula: C27H25Cl2N7O7
| CAS | 412960-54-4 |
|---|---|
| Molecular Formula | C27H25Cl2N7O7 |
Tocris Bioscience™ Dihydro-β-erythroidine hydrobromide
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CAS: 29734-68-7 Molecular Formula: C16H22BrNO3
| CAS | 29734-68-7 |
|---|---|
| Molecular Formula | C16H22BrNO3 |